After taking the medicine, I found that I was pregnant. Can children ask?

During the clinic, I often encountered patients with the color Doppler ultrasound list that confirmed pregnancy.

In fact, this problem is indeed more complicated.Doctors need to comprehensively evaluate the last menstrual time, category, dosage, time, etc. of each patient.At the same time, we must also understand the teratogenic sensitivity period and drug safety classification of embryo development.

The teratogenic sensitive period of embryonic development

After the eggs are fertilized, the development of embryos and fetus is divided into three stages: early embryo, embryo period, and fetal stage.

During the non -sensitive period (early embryo)

Within 28 days after the last menstruation, 0 to 2 weeks after fertilization (2-4 weeks of pregnancy).

In this period, the impact of drugs on the embryo is "all or no": either the embryo died (all) due to the impact of the damage to the drug, or the fetus was not affected by the drug (none).

Drugs are used during this period, which generally does not cause fetal malformations.

Sensitive period (embryo period)

Within 29 days to 70 days after the last menstruation, 3-8 weeks after fertilization (5-10 weeks of pregnancy).

This period is a period of fetal organs. For example, if the brain is 15-27 days after conception, the eyes are 24-29 days, the heart is 20-29 days, the limbs are 24-36 days, and the genitals are 26-62 days.

During this period, embryos are most sensitive to drugs and prone to severe malformations.

Low sensitive period (fetal period)

9-38 weeks after fertilization, that is, 11-40 weeks of pregnancy.

This period is the stage of fetal growth, organ development, and perfect function, but the nervous system, reproductive organs, and teeth are still continuing to differentiate, especially the nervous system differentiation, development, and proliferation reaching a peak.

During this period of medication, the impact of drugs mainly involves fetal growth and organ function, such as limited fetal growth, low birth weight, abnormal functional behavior, premature birth, etc.

Drug safety classification

The US Food and Drug Administration (FDA) divides the safety of drugs into five categories: A, B, C, D, and X:

1. Grade A: In the drug research in the control group, women who have not seen the drug in the first three months of pregnancy show signs of harm to the fetus (and there is no evidence of harmfulness in the next 6 months). This should beThe impact of drugs on the fetus has a little impact.

2. Grade B: In the research of animal reproduction (no comparison study of pregnant women), no drug has a adverse effect on the fetus.Or find that drugs have side effects in animal reproductive studies, but these side effects have not been confirmed among women who are in control and 3 months of pregnancy (and have not been harmful to the next six months).

3. Class C: Animal studies have proved that drugs are harmful to the fetus (teratogenic or embryonic death, etc.), or no comparison of pregnancy women’s research, or have not yet studied pregnant women and animals.This type of drugs can only be used only after weighing the benefits of pregnant women than the harm to the fetus.

4. Class D: There are clear evidence that drugs are harmful to human fetuses, but despite this, pregnant women are definitely beneficial after medication (for example, using this drug to save pregnant women’s lives, or treat other safer severe diseases that are not effective drugs.To.

5. Grade X: The experience of drug research on animals and human beings or human medication shows that drugs are harmful to fetus, and pregnant women are not beneficial to the application of such drugs, so they are disabled in patients with pregnancy or possible pregnancy.

After the doctors analyze the nature of the drug, the half -life of the drug, the reproductive toxicity, the toxic target organs, and the last time of medication will be given, it will give advice to whether to continue pregnancy.If you are allowed to continue your pregnancy, you need to pay a regular check -up, pay close attention to the development of the fetus, maintain a happy mood, and go through pregnancy.


Precautions for medication during pregnancy

2. Early pregnancy is the differential stage of the fetal body and organs. Drug teratogenic is prone to occur at this stage. The safety of drugs for medium and advanced pregnancy has increased.It is through the entire stage of pregnancy.

3. Drugs without pregnancy do not mean that it is absolutely safe for pregnant women. Please refer to the "pregnant women and breastfeeding women medicine" part of the complete drug information.For example, most topical drugs do not have a pregnancy stage, because in general, only trace external drugs can be absorbed in the body through the skin.However, if it is used for long -term and large -scale use of external drugs, the drug content in the body will increase.Other traditional Chinese medicinal materials, Chinese medicines and slices are also no grades of pregnancy, but the application of pregnancy must also attract sufficient attention.

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