Pregnant women’s obesity increases the risk of cardiovascular disease for descendants

The rapid increase in the obese population has affected nearly one -third of the childlike age women.A study published in the "Physiology Magazine" on May 12 pointed out that mother’s obesity can damage the fetal health and function of the fetus.

Studies have found that mother obesity can lead to changes in the heart of the fetal heart and change the genetic expression related to nutritional metabolism, which greatly increases the risk of heart problems in the future.This is the first research that the heart is "programming" by the heart received by the fetus.

The changes in gene expression change the way the heart metabolizes the carbohydrate and fat of the heart.They further turn the nutritional preferences of the heart to fat, not sugar. As a result, the heart of the obese female fetus becomes larger, heavier, and thicker myocardium, and shows signs of inflammation.This will reduce the efficiency of heart contraction and transport blood to the whole body.

Researchers at the University of Colorado use a mouse model that copy the physiology and placental nutrient transportation model of obese women.

In the study, the female rats were fed with high -fat diet and sugar -containing drinks, which is equivalent to eating burgers, fries and carbonated beverages (about 1500 kcal).Female rats have been eating these foods until the weight increases by 25%.The other 50 female rats were controlled as a control group.

Researchers use ultrasonic heart -mouther and positive electronic launch fault scanning and other imaging technologies to study the mouse cubs of 3 months, 6 months, 9 months, and 24 months after birth.Gene, protein and mitochondria.

It was found that the changes in descendants’ metabolism were closely related to gender.There are 841 gene expression in the heart of female fetuses, and there are 764 male fetal hearts, but less than 10%of gene expression in the sexes has changed.

However, there are differences in changes between gender -male heart function has been damaged from the beginning, and female heart function gradually deteriorates with age.

The gender difference between cardiovascular health and continuous damage may be caused by estrogen, but the molecular causes of gender differences are unclear.

The first author of the dissertation, Owen Vaughan at the University of Colorado said: "Our research shows that there is a correlation between mother’s obesity with future heart metabolic diseases.Lave the road. "

For example, people can provide them with more targeted nutritional advice based on their mother or children’s weight index or gender, or develop new drugs for fetal heart metabolism.

Researchers pointed out that mice have a short pregnancy time, many future generations, and diet are different from humans. Therefore, research needs to be studied among human volunteers to further prove the exact molecular mechanism of mother’s obesity and descendants’ heart function.(Wang Fang)

Related thesis information:

https://doi.org/10.1113/jp282462

Source: Journal of Science

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